The effects of sympathetic neurotransmitters and adrenergic receptors on liver fibrosis in murine schistosomiasis / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 352-354, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-332236
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of sympathetic neurotransmitters and adrenergic receptors on liver fibrosis in murine schistosomiasis.</p><p><b>METHODS</b>Mice were infestated with schistosoma by means of pasting cercariae on their abdomens. Thirty mice were randomly divided into a control group and a model group. Hematoxylin eosin and Van Gieson staining were used to view the histopathology of their livers. Immunofluorescence histochemistry and laser scanning confocal fluorescence microscopy were used to measure the a1A and beta2 adrenergic receptors in livers of the two groups of mice. High performance liquid chromatography-electrochemical detector (HPLC-ECD) was used to determine the concentration of norepinephrine (NE) and dopamine (DA) in the plasma of the mice.</p><p><b>RESULTS</b>Immunofluorescence histochemistry showed that a1A and beta2 receptors were present in hepatocytes and hepatic sinusoids of the livers of the mice of the two groups, but there were many more in the livers of the schistosoma infected mice (t=-2.888; t=-6.648) (P<0.05). The results of HPLC-ECD showed that the levels of NE and DA in the model group were higher than those of the control group (t=-3.372; t=-4.428) (P<0.05).</p><p><b>CONCLUSION</b>Sympathetic neurotransmitters and adrenergic receptors may participate in liver fibrogenesis in mice infected with schistosoma.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Parasitologie
/
Anatomopathologie
/
Schistosomiase
/
Sang
/
Dopamine
/
Norépinéphrine
/
Récepteurs adrénergiques
/
Agents neuromédiateurs
/
Foie
/
Cirrhose du foie
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2008
Type:
Article
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