Enhancing active immunity against hepatitis B virus by HBV vaccine immunization in patients with HBV-related end-stage liver diseases treated with liver transplantation / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 261-264, 2008.
Article
Dans Zh
| WPRIM
| ID: wpr-332261
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To study the active immunity response of liver transplant patients for HBV-related diseases after hepatitis B virus (HBV) vaccine immunization and to investigate the factors that influence the effectiveness of the vaccination in order to find measures to increase its success.</p><p><b>METHODS</b>Thirteen patients who had liver transplants because of HBV-related end-stage liver diseases received hepatitis B virus immunoglobulin and lamivudine for an average of 38 months (range 27-77 months). They received double intramuscular doses (40 microg) of a recombinant vaccine at months 0, 1, 2 and 6. The anti-HBs titers were tested regularly at months 1, 2, 3, 6 and 7.</p><p><b>RESULTS</b>Seven of the 13 patients (53.8%) developed higher serum titers of anti-HBs compared with their titers prior to the vaccinations, 2 patients of the 13 (15.4%) developed an increase by 100 U/L and in 4 patients (30.8%) their base levels were doubled. Those responding patients were followed-up for another 8 months after the fourth vaccination, and only 1 patient among them had a decrease of the anti-HBs titers below the level prior to the vaccination.</p><p><b>CONCLUSION</b>Hepatitis B vaccine immunization can be used to enhance the active immunity against HBV in patients who had liver transplants for HBV-related diseases.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Période postopératoire
/
Virologie
/
Virus de l'hépatite B
/
Transplantation hépatique
/
Vaccins anti-hépatite B
/
Utilisations thérapeutiques
/
Allergie et immunologie
/
Hépatite B
/
Immunité active
/
Maladies du foie
Limites du sujet:
Adult
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Chinese Journal of Hepatology
Année:
2008
Type:
Article