The level of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and nonalcoholic fatty liver / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the roles of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and Nonalcoholic fatty liver.</p><p><b>METHODS</b>The level of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and Nonalcoholic fatty liver was detected by ELISA after culturing for 72 hours in vitro, as well as patients with chronic hepatitis C and the normal control.</p><p><b>RESULTS</b>(1) Compared with the normal control, the level of TNF-alpha in group with chronic hepatitis C and in group with chronic hepatitis C and Nonalcoholic fatty liver notably increased. (2) Compared with the group with chronic hepatitis C, the level of TNF-alpha in group with chronic hepatitis C and Nonalcoholic fatty liver also notably increased.</p><p><b>CONCLUSION</b>It suggested TNF-alpha takes important roles in the infection course of chronic hepatitis C with Nonalcoholic fatty liver.</p>