Effect of L-838,417 on pain behavior in a rat model of trigeminal neuralgia / 南方医科大学学报
Journal of Southern Medical University
;
(12): 890-893, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-332524
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of L-838,417 on the results of behavioral test in rats with experimentally induced trigeminal neuralgia.</p><p><b>METHODS</b>Male SD rats were randomized into model group (n=34), sham-operated group (n=30) and control group (n=6). Thirty rats with trigeminal neuralgia induced by chronic constriction injury of the infraorbital nerve below the zygomatic bone were randomly divided into 5 equal groups for treatment with 1.0 mg/kg L-838,417 (L1 group), 10.0 mg/kg L-838,417 (L10 group), 5 mg/kg morphine (M group), 3 mg/kg diazepam (D group), or normal saline (NS group). The pain threshold of the tentacles pad to von-Frey filament stimulation was measured in the rats before and at 1, 2, 3, 4, 5 h after the treatments. The sedative effect of L-838,417 was evaluated by recording the position scores and righting reflex scores, and the drug tolerance was also evaluated.</p><p><b>RESULTS</b>Nine days after the operation, the pain threshold of the rats in the model group was significantly decreased compared with that before operation and that of the sham group (P<0.01). The threshold of L1 and L10 groups were both significantly increased 1 h after L-838,417 administration (P<0.01). The rats in the NS, L1, and L10 groups did not show unusual posture or righting reflex. In L1 and L10 groups, L838,417 did not show attenuated efficacy after prolonged use (10 days).</p><p><b>CONCLUSION</b>L-838,417 can effectively improve hyperalgesia in rats with trigeminal neuralgia without causing sedation, motor impairment, or drug tolerance.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Triazoles
/
Névralgie essentielle du trijumeau
/
Mesure de la douleur
/
Rat Sprague-Dawley
/
Seuil nociceptif
/
Traitement médicamenteux
/
Fluorobenzènes
/
Hyperalgésie
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2011
Type:
Article
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