Microarray data analysis of genes related with erectile dysfunction in diabetic rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 694-697, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-332572
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes of gene expression profiles associated with erectile dysfunction in diabetic rats.</p><p><b>METHODS</b>Affymetrix Gene Chip arrays from the Gene Expression Omnibus (GEO) were used to examine the alterations in the gene expression profiles between streptozotocin-induced diabetic rats and littermate controls, and the data were analyzed with GeneSifter microarray analysis software.</p><p><b>RESULTS</b>A total of 661 differentially expressed genes were identified, including 280 up-regulated and 381 down-regulated ones. Among the differentially expressed genes, kruppel-like factor 5 (klf5) was upregulated by 4.01 folds and ceruloplasmin(cp) by 5.14 folds; collagen, type XI, alpha1 was down-regulated by 5.84 folds and collagen, type I, alpha1 by 5.77 folds. The 661 differentially expressed genes involved such functional processes as glycoprotein biosynthesis, collagen fibril organization, angiogenesis in wound healing, triglyceride metabolism, cell proliferation and other important biological processes, and some pathways also involved such as fatty acid metabolism, neurodegenerative disorders, and ECM-receptor interactions.</p><p><b>CONCLUSION</b>Some genes such as klf5, cp, and collagen play important roles in the pathophysiology of diabetes-induced erectile dysfunction. Bioinformatic approaches offer a new means for identifying candidate genes and pathways relevant to the pathophysiology of diabetes-induced erectile dysfunction, highlighting also the potential complexity of this disorder.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Expression des gènes
/
Biologie informatique
/
Séquençage par oligonucléotides en batterie
/
Analyse de profil d'expression de gènes
/
Diabète expérimental
/
Génétique
/
Dysfonctionnement érectile
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2011
Type:
Article
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