Repair of radius defect with bone-morphogenetic-protein loaded hydroxyapatite/collagen-poly(L-lactic acid) composite / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 67-74, 2003.
Article
Dans Anglais
| WPRIM
| ID: wpr-332915
ABSTRACT
<p><b>OBJECTIVE</b>To explore the method to repair bone defect with bone-morphogenetic-protein loaded hydroxyapatite/collagen-poly(L-lactic acid) composite.</p><p><b>METHODS</b>18 adult beagle dogs were randomly divided into 3 groups. In Group A, bone-morphogenetic-protein (BMP) loaded hydroxyapatite/collagen-poly(L-lactic acid) (HAC-PLA) scaffold was implanted in a 2 cm diaphyseal defect in the radius. In Group B, unloaded pure HAC-PLA scaffold was implanted in the defects. No material was implanted in Group C (control group). The dogs were sacrificed 6 months postoperatively. Features of biocompatibility, biodegradability and osteoinduction were evaluated with histological, radiological examinations and bone mineral density (BMD) measurements.</p><p><b>RESULTS</b>In Group A, the radius defect healed after the treatment with BMP loaded HAC-PLA. BMD at the site of the defect was higher than that of the contralateral radius. Fibrous union developed in the animals of the control group.</p><p><b>CONCLUSIONS</b>BMP not only promotes osteogenesis but also accelerates degradation of the biomaterials. Optimized design parameters of a three-dimensional porous biomaterial would give full scope to the role of BMP as an osteoinductive growth factor.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ostéogenèse
/
Anatomopathologie
/
Physiologie
/
Radius
/
Cicatrisation de plaie
/
Matériaux biocompatibles
/
Imagerie diagnostique
/
Microscopie électronique à balayage
/
Radiographie
/
Ostéo-intégration
Type d'étude:
Etude diagnostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Chinese Journal of Traumatology
Année:
2003
Type:
Article
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