Analysis on prognostic factors of liver failure in children / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 16-18, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-333062
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the prognostic factors of liver failure in children.</p><p><b>METHODS</b>The clinical data of 105 children with liver failure treated in the No. 302 Hospital in the past 17 years were retrospectively analyzed. The related factors were analysed by EXCELL 2000 and STATA 7.0, multivariate statistical analysis was performed by Logistic regression.</p><p><b>RESULTS</b>(1) A total of 72 children died and the mortality was 68.6%. (2) Univariate statistical analysis showed that the factors significantly correlated with death were age, clinical type and stage of liver failure, decrease in prothrombin activity (PTA) and albumin (AIB) level, increase in serum level of total bilirubin (TBIL), appearance of deviation of TBIL and ALT, complications and hepatic encephalopathy. There was no significant difference between boys and girls. (3) There was no significant difference among etiological diagnoses such as HBV infection, Wilson's disease, and unknown pathogeny. (4) Multivariate statistical analysis showed that PTA (P = 0.000) and TBIL (P = 0.029) were independent risk factors of mortality of the children.</p><p><b>CONCLUSION</b>The prognosis of liver failure in children is poor and mortality is high. PTA and TBIL might be useful for indicating prompt diagnosis and treatment to improve survival rate of the children with liver failure.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Modèles logistiques
/
Analyse multifactorielle
/
Taux de survie
/
Études rétrospectives
/
Facteurs de risque
/
Mortalité
/
Facteurs âges
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Défaillance hépatique
/
Diagnostic
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Bébé
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Experimental and Clinical Virology
Année:
2005
Type:
Article
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