Expression of lipopolysaccharide receptors CD14 and TLR4 in a model of rat molar apical periodontitis / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 148-149, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-333382
ABSTRACT
<p><b>OBJECTIVE</b>To characterize the expression of lipopolysaccharide (LPS) receptors-CD14 and TLR4 in rat peri-radicular tissue and to investigate the signal transduction pathway of LPS and its receptors in periapical periodontitis.</p><p><b>METHODS</b>After establishment of a model of rat molar LPS-induced apical periodontitis, CD14 and TLR4 expression in healthy and inflammatory periapical tissue were determined by immunohistochemistry.</p><p><b>RESULTS</b>CD14 and TLR4 were not detected in healthy periapical tissue but strongly positive in inflammatory periapical tissue. Positive cells were mostly monocytes/macrophages.</p><p><b>CONCLUSIONS</b>CD14 and TLR4 may play an important role in the pathogenesis of periapical periodontitis, probably via immune cells such as monocytes/macrophages and neutrophils.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Parodontite périapicale
/
Transduction du signal
/
Lipopolysaccharides
/
Rat Sprague-Dawley
/
Antigènes CD14
/
Modèles animaux de maladie humaine
/
Récepteur de type Toll-4
/
Toxicité
/
Métabolisme
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Stomatology
Année:
2007
Type:
Article
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