Relationship between plasma carbon monoxide and blood-brain barrier permeability in cirrhotic rats / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 129-131, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-334291
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between plasma levels of carbon monoxide and blood-brain permeability in cirrhotic rats.</p><p><b>METHODS</b>We measured mean arterial pressure (MAP), heart rate, plasma levels of carbon monoxide and amount of Evans blue in the brain tissue taken as the index of blood-brain permeability in cirrhotic rats (n=10) and controls (n=10).</p><p><b>RESULTS</b>Cirrhotic rats showed significant increases in plasma carbon monoxide and amount of Evans blue in brain tissue compared with controls [(18.37 +/- 1.79) micromol/L,(18.52 +.- 1.39) ng/mg vs (10.27 +/- 1.21) micromol/L, (15.08 +/- 1.06) ng/mg; P< 0.01]. Carbon monoxide levels in cirrhotic rats correlated positively with blood-brain barrier permeability and inversely with MAP (r=0.72, P< 0.01; r= -0.67, P< 0.05).</p><p><b>CONCLUSIONS</b>Carbon monoxide, involving in the occurrence of hypotension and the increase of blood-brain barrier permeability, may play a role in the development of hepatic encephalopathy.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Aspartate aminotransferases
/
Sang
/
Pression sanguine
/
Perméabilité capillaire
/
Monoxyde de carbone
/
Tétrachloro-méthane
/
Barrière hémato-encéphalique
/
Rat Sprague-Dawley
/
Alanine transaminase
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2002
Type:
Article
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