The value of gamma-glutamyltransferase in the diagnosis of chronic hepatitis B / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 120-122, 2002.
Article
de Zh
| WPRIM
| ID: wpr-334294
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the change of serum gamma-glutamyltransferase (GGT) and its diagnosis value in chronic hepatitis B (CHB) patients with different degrees of liver damage.</p><p><b>METHODS</b>Alanine-aminotransferase (ALT), aspartate-aminotransferase (AST) and GGT were measured in 221 CHB patients. Liver biopsy was conducted simultaneously to determine the inflammation grade and fibrosis stage of the liver tissues.</p><p><b>RESULTS</b>The rate of normal GGT in pathologically diagnosed mild and severe CHB patients was 90.4% and 12.3%, respectively (P<0.01). Increased level of GGT was parallel to the degree of liver pathological change (P<0.01). In active CHB patients, GGT rose with the ALT increase with a positive linear correlation between them (r=0.464, P<0.001). In pathologically diagnosed mild CHB patients, GGT had a tendency of rapidly declining to normal levels with ALT. In moderate CHB patients, GGT fluctuated at a relatively high level, and in severe CHB patients GGT exhibited a deviation from GGT.</p><p><b>CONCLUSIONS</b>GGT is conducive to improve the coincident rate between the clinical and pathological diagnosis of CHB.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
Aspartate aminotransferases
/
Facteurs temps
/
Sang
/
Indice de gravité de la maladie
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Fibrose
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Valeur prédictive des tests
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Hépatite B chronique
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Diagnostic
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Alanine transaminase
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
Limites du sujet:
Adult
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Chinese Journal of Hepatology
Année:
2002
Type:
Article