Recombinant HEV caspid protein p239 specifically attached on HepG2 cells and blocked the infection of wild-type HEV on liver cells / 病毒学报
Chinese Journal of Virology
;
(6): 331-334, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-334888
ABSTRACT
By using Western blot and immunofluorescence assays, the recombinant HEV capsid protein p239 was found specifically attached to the HepG2 cell surface and entered to the cytoplasm with the increase of incubation temperature. Pre-mixture of wild-type HEV with p239 blocked the infectivity of the virus on primary cultured human hepatocytes and HepG2 cells, indicating that p239 and HEV competed the same targeting site on these cells. These data provide evidence that p239 has a similar cell surface structure with wild-type HEV.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Liaison aux protéines
/
Facteurs temps
/
Virologie
/
Protéines recombinantes
/
Technique de Western
/
Technique d'immunofluorescence
/
Virus de l'hépatite E
/
RT-PCR
/
Hépatocytes
/
Protéines de capside
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Virology
Année:
2007
Type:
Article
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