The microstructural effects of aqueous extract of Garcinia kola (Linn) on the hippocampus and cerebellum of malnourished mice
Asian Pacific Journal of Tropical Biomedicine
;
(12): 261-265, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-335032
ABSTRACT
<p><b>OBJECTIVE</b>To assess the neuroprotective effects of aqueous extract of Garcinia kola on neurotoxin administered malnourished mice adopting histological procedure.</p><p><b>METHODS</b>The study was carried out using thirty-two adult malnourished mice which were randomly assigned into four groups (n=8) A, B, C and D. Group A served as control, while the other groups served as the experimental groups. Animals in group A were fed malnourished diet ad libitum and given water liberally. Animals in group B were administered with 3-Nitropropionic acid (3-NP) (neurotoxin) only at 20 mg/kg body weight, group C were given only Garcinia kola extracts, and group D were pre-treated with Garcinia kola extracts at 200 mg/kg for seven days prior to administration of neurotoxin at 20 mg/kg body weight. After three days of neurotoxins administration in the relevant groups, the brains were excised and fixed in formal calcium for histological processing.</p><p><b>RESULTS</b>The study showed that hippocampal and cerebellar neurons of animals in group B exhibited some cellular degeneration and blood vessel blockage, which were not seen in groups A, C and D. Cresyl violet staining was least intense in group B than in groups A, C and D. Despite the fact that animals in group D has equal administration of 3-Nitropropionic acid concentration, there were no traces of neural degeneration as it was evidenced in group B.</p><p><b>CONCLUSIONS</b>It is concluded that Garcinia kola has protective effects on the neurons of the hippocampus and cerebellum of malnourished mice.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Extraits de plantes
/
Cervelet
/
Chimie
/
Résultat thérapeutique
/
Neuroprotecteurs
/
Garcinia kola
/
Malnutrition
/
Traitement médicamenteux
/
Hippocampe
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Asian Pacific Journal of Tropical Biomedicine
Année:
2011
Type:
Article
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