Association between HLA-DQA1 gene copy number polymorphisms and susceptibility to gastric cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 269-271, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-335298
ABSTRACT
<p><b>OBJECTIVE</b>To explore the association between HLA-DQA1 gene copy number polymorphisms and gastric cancer risk in Chinese population, and the interaction of those genes and environmental factors.</p><p><b>METHODS</b>The genotype of HLA-DQA1 gene copy number polymorphisms was determined in 343 patients with gastric cancer and 330 controls by quantitative polymerase chain reaction. Logistic regression model was used to evaluate the impact of this polymorphism on the risk of developing gastric cancer and the gene-environment interaction.</p><p><b>RESULTS</b>Compared with 0 copy of HLA-DQA1 gene carriers, the 2 copies of HLA-DQA1 gene carriers had a significantly increased risk of gastric cancer (OR = 1.87, 95%CI = 1.15 - 3.06, P = 0.012). Gene-environment interaction of HLA-DQA1 gene copy number polymorphisms and Helicobacter pylori infection significantly increased the risk of gastric cancer in a multiplicative manner, with an OR of 3.89 (95%CI = 1.75 - 8.57, P = 0.001).</p><p><b>CONCLUSIONS</b>HLA-DQA1 gene copy number polymorphism is associated with gastric cancer susceptibility, and there is a multiplicative gene-environment interaction between this polymorphism and Hp infection in the development of gastric cancer.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs de l'estomac
/
Facteurs de risque
/
Infections à Helicobacter
/
Prédisposition génétique à une maladie
/
Allergie et immunologie
/
Variations de nombre de copies de segment d'ADN
/
Chaines alpha des antigènes HLA-DQ
/
Interaction entre gènes et environnement
/
Génétique
/
Génotype
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2012
Type:
Article
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