Predictive value of fluorescence in situ hybridization in patients with bladder cancer / 南方医科大学学报
Journal of Southern Medical University
; (12): 1597-1603, 2010.
Article
de Zh
| WPRIM
| ID: wpr-336132
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the value of fluorescence in situ hybridization (FISH) in the diagnosis of bladder cancer.</p><p><b>METHODS</b>Urine samples from 100 patients suspected of having bladder cancer were collected before cystoscopy for immediate urine cytology and FISH analysis. The criteria for FISH abnormality were determined by evaluating the urine specimens from 20 subjects without urogenital neoplasm.</p><p><b>RESULTS</b>The overall sensitivity of cytology and FISH was 43.2% and 82.4%, and their specificity was 92.3% and 88.5%, with diagnostic concordance rate of 56.0% and 84.0%, respectively. The differences between FISH and cytology showed statistical significance in the sensitivity, diagnostic concordance rate, non-muscle-invasive cancer and primary cancer.</p><p><b>CONCLUSION</b>The sensitivity and efficiency of FISH in the detection of bladder cancer are superior to those of cytology, especially for prophase cancer.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Urine
/
Tumeurs de la vessie urinaire
/
Carcinome transitionnel
/
Sensibilité et spécificité
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Hybridation fluorescente in situ
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Cytodiagnostic
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Biologie cellulaire
/
Diagnostic
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
Limites du sujet:
Adolescent
/
Adult
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Aged
/
Aged80
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Female
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Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Southern Medical University
Année:
2010
Type:
Article