Effect of the ethanol extract of Picrorhiza scrophulariiflora on the progression of chronic kidney disease in a rat remnant kidney model / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1505-1508, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-336156
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of the ethanol extract of Picrorhiza scrophulariiflora (EPS) on renal function and tissue damage in a rat remnant kidney model.</p><p><b>METHODS</b>Rat models of chronic kidney disease induced by 5/6 nephrectomy (5/6 Nx) were randomly assigned into two groups for treatment with a gavage of either EPS or vehicle for 9 weeks. The rats in the control group received only sham operation.</p><p><b>RESULTS</b>Compared with vehicle-treated 5/6 Nx rats, the EPS-treated rats displayed significantly decreased urinary excretion of malondialdehyde, serum levels of AGEs and AOPPs, and increased serum SeGSHPx activities. These changes were associated with attenuated urinary protein excretion, glomerular sclerosis and interstitial fibrosis.</p><p><b>CONCLUSION</b>EPS can obviously improve the renal functions and renal pathologies in rats with chronic kidney disease probably by inhibiting the oxidative stress.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Médicaments issus de plantes chinoises
/
Chimie
/
Rat Sprague-Dawley
/
Stress oxydatif
/
Évolution de la maladie
/
Picrorhiza
/
Utilisations thérapeutiques
/
Traitement médicamenteux
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2010
Type:
Article
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