Uncoupling protein-2 expression in granular cells and embryo development in in vitro fertilization-embryo transfer cycle / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1077-1079, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-337320
ABSTRACT
<p><b>OBJECTIVE</b>To examine the expression of uncoupling protein-2 (UCP2) in the granular cell of women undergoing in vitro fertilization (IVF) and explore its role in embryo development.</p><p><b>METHODS</b>In this prospective study, the levels of UCP2 and reactive oxygen species (ROS) were measured by the chemiluminescence method in the granular cell of 53 women.</p><p><b>RESULTS</b>Women with low UCP2 level had higher ROS level, suggesting an inverse relationship between them (r=-0.578, P<0.01), and their oocyte development was impaired. Granular cells of elder women exhibited lowered UCP2 expression.</p><p><b>CONCLUSION</b>The granular cells increase UCP2 expression to suppress the elevation of intracellular ROS level through a feedback mechanism and therefore protect the oocytes against oxidative stress.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Vieillissement
/
Fécondation in vitro
/
Régulation de l'expression des gènes
/
Espèces réactives de l'oxygène
/
Biologie cellulaire
/
Protéines mitochondriales
/
Développement embryonnaire
/
Transfert d'embryon
/
Protéine-2 de découplage
/
Infertilité féminine
Type d'étude:
Étude observationnelle
Limites du sujet:
Animaux
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2007
Type:
Article
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