Relationship between hepatitis B virus genotypes and liver fibrosis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1012-1014, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-337335
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between hepatitis B virus (HBV) genotypes and liver fibrosis.</p><p><b>METHODS</b>Polymerase chain reaction-restriction fragment length polymorphism method was employed to determine HBV genotypes in 298 HBV-related liver disease patients, including 73 with hepatocellular carcinoma, 53 with liver cirrhosis, 91 with chronic hepatitis B and 82 asymptomatic HBV carriers to analyze the relationship of HBV genotypes with serum fibrous indices and serum albumin and globulin (A/G) ratio.</p><p><b>RESULTS</b>B and C genotypes were dominant in patients with HBV-related hepatic diseases in Guangdong province. The levels of serum fibrous indices were significantly higher in patients with genotype C than in those with genotype B, and the former patients also had lower A/G ratio.</p><p><b>CONCLUSION</b>Patients with HBV genotype C may sustain more serious liver injury.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Virologie
/
Sang
/
Virus de l'hépatite B
/
Hépatite B chronique
/
Génétique
/
Génotype
/
Cirrhose du foie
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2007
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS