Study on material base of Ligusticum wallichii for treating brain ischemia and its molecular mechanism based on molecular docking / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2195-2198, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-337960
ABSTRACT
To explore the effective ingredients and mechanism of Ligusticum wallichii in treating brain ischemia. Four brain ischemia-related target proteins were selected in the joint screening for the 45 component in L. wallichii reported in literatures based on molecular docking by reference to the corresponding drugs in the market. According to the docking results, multiple components in L. wallichii, such as phthalides, were superior to the corresponding drugs in the market, suggesting that they may be the major effective components in L. wallichii for treating brain ischemia. The method can be used to study the material base and molecular mechanism of traditional Chinese medicines.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Encéphalopathie ischémique
/
Chimie
/
Facteur de nécrose tumorale alpha
/
Myeloperoxidase
/
Ligusticum
/
Traitement médicamenteux
/
Nitric oxide synthase type II
/
Simulation de docking moléculaire
/
Médecine traditionnelle chinoise
/
Phytothérapie
Type d'étude:
Etude diagnostique
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2015
Type:
Article
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