Inflammatory skin response to photochemotherapy: ear swelling response in C57BL mouse model / 대한피부과학회지
Korean Journal of Dermatology
; : 608-615, 1992.
Article
de Ko
| WPRIM
| ID: wpr-33797
Bibliothèque responsable:
WPRO
ABSTRACT
We have observed the dark effect of 8-methoxypsoralen(8-M(P) on the viability and DNA synthesis in human lymphocyte cultures after stimulaticn with phytohemagglutinin (PHA) in the absence of ultraviolet A radiation. The concentratioiis of 8-MOP was 0.5-32 ug/ml. We have also measured the LDH activity in supernatant. of lymphocyte cultures treated with 8-MOP. The results were as follows: 1. There was no 8-MOP dose-dependent decrease in the viability of lymphocytes up to 8- MOP 32pg/ml. 2. There was a 8-MOP dose-dependent decrease in PHA-induced DNA synthesis of lymphocytes from the concentration of 8-MOP 2 ug/ml. 3. There was a time-dependent decrease in PHA-induced DNA synthesis of lymphocytes at the concentration of 8-MOP 32 ug/ml. 4. There was no LDH release in supernatant of lymphocyte ciltu es after incubation with 8-MOP up to 8-MOP 32ug/ml.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Photothérapie dynamique
/
Peau
/
ADN
/
Lymphocytes
/
Oreille
/
Méthoxsalène
/
Souris de lignée C57BL
Limites du sujet:
Animals
/
Humans
langue:
Ko
Texte intégral:
Korean Journal of Dermatology
Année:
1992
Type:
Article