Effect of genetic polymorphism of MTNR1A gene on adolescent idiopathic scoliosis / 中华外科杂志
Chinese Journal of Surgery
; (12): 1264-1266, 2007.
Article
de Zh
| WPRIM
| ID: wpr-338177
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether the MTNR1A gene promotor polymorphism (rs2119882) are associated with the occurrence or curve severity of adolescent idiopathic scoliosis (AIS).</p><p><b>METHODS</b>226 AIS patients and 277 normal controls were recruited. The maximum Cobb angles were recorded in AIS patients. PCR-RFLP was used for the genotyping.</p><p><b>RESULTS</b>The genotype and allele frequency distribution were comparable between AIS and normal control, the mean maximum Cobb angle of different genotypes of rs2119882 were similar with each other among AIS patients.</p><p><b>CONCLUSION</b>The MTNR1A gene promoter polymorphism was neither associated with the occurrence nor the curve severity of AIS.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Polymorphisme génétique
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Scoliose
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Polymorphisme de restriction
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Réaction de polymérisation en chaîne
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Prédisposition génétique à une maladie
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Récepteur de la mélatonine de type MT1
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Fréquence d'allèle
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Génétique
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Génotype
Limites du sujet:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Surgery
Année:
2007
Type:
Article