Role of long non-coding RNAs in gene regulation and oncogenesis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2378-2383, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-338542
ABSTRACT
<p><b>OBJECTIVE</b>This article aims to review recent studies on the biological characteristics of long non-coding RNAs (lncRNAs), transcription regulation by lncRNAs, and the results of recent studies on the mechanism of action of lncRNAs in tumor development.</p><p><b>DATA SOURCES</b>The data cited in this review were mainly obtained from the articles listed in PubMed and HighWire that were published from January 2002 to June 2010. The search terms were "long non-coding RNA", "gene regulation", and "tumor".</p><p><b>STUDY SELECTION</b>The mechanism of lncRNAs in gene expression regulation, and tumors concerned with lncRNAs and the role of lncRNAs in oncogenesis.</p><p><b>RESULTS</b>lncRNAs play an important role in transcription regulation by controlling chromatin remodeling, transcriptional control, and post-transcriptional controlling. lncRNAs are involved in many kinds of tumors and play key roles as both suppressing and promoting factors.</p><p><b>CONCLUSION</b>lncRNAs could perfectly regulate the balance of gene expression system and play important roles in oncogenic cellular transformation.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Transformation cellulaire néoplasique
/
Régulation de l'expression des gènes
/
ARN non traduit
/
Génétique
/
Tumeurs
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Chinese Medical Journal
Année:
2011
Type:
Article
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