Expression of Aurora-B in human glioma tissue and its significance / 南方医科大学学报
Journal of Southern Medical University
; (12): 47-49, 2009.
Article
Dans Zh
| WPRIM
| ID: wpr-339069
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of Aurora-B in human glioma tissue and its significance.</p><p><b>METHODS</b>The total RNA was extracted from 41 human glioma tissues and 11 normal brain tissues by Trizol reagent. After reverse transcription of the total RNA into cDNAs, Aurora-B mRNA expressions in these samples were detected by quantitative real-time PCR. The protein expression in these samples was detected using immunohistochemical staining.</p><p><b>RESULTS</b>Aurora-B mRNA and protein expressions were significantly increased in glioma tissues as compared with those in normal brain tissues.</p><p><b>CONCLUSION</b>Aurora-B mRNA and protein show markedly higher expressions in glioma tissue, suggesting that Aurora-B may be one of the malignant biomarkers in the pathogenesis and progression of human glioma.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
Tumeurs du cerveau
/
ARN messager
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Cellules cancéreuses en culture
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Marqueurs biologiques tumoraux
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Protein-Serine-Threonine Kinases
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Aurora kinases
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Aurora kinase B
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Génétique
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Gliome
Limites du sujet:
Female
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Humans
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Male
langue:
Zh
Texte intégral:
Journal of Southern Medical University
Année:
2009
Type:
Article