Influence of SEN virus infection on their response to lamivudine in patients with chronic hepatitis B / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 683-685, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-339120
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of SEN virus infection on their response to lamivudine in patients with chronic hepatitis B (CHB).</p><p><b>METHODS</b>SEN virus-D and -H DNA were detected in 45 CHB patients who received lamivudine 12 months with nested-PCR, and YMDD motif mutations in HBV DNA were investigated with gene chip.</p><p><b>RESULTS</b>The positive rate of SEN virus DNA was 11.1% (5/45), and there were four out of the five SEN virus DNA positive patients whose HBV DNA was positive, among them, two patients existed YMDD motif mutation. While ten out of the forty SEN virus DNA negative patients appeared HBV DNA positive. The response rate was significant lower in SEN virus-infected patients than that in uninfected patients (chi 2=3.97, P<0.05).</p><p><b>CONCLUSION</b>Coinfection with SEN virus in chronic hepatitis B patients may adversely affect the outcome of treatment with lamivudine</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Infections à respirovirus
/
Pharmacologie
/
Virologie
/
ADN viral
/
Virus de l'hépatite B
/
Lamivudine
/
Agents antiVIH
/
Hépatite B chronique
/
Virus Sendai
/
Génétique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2003
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS