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Evidence of bacterial biofilms in chronic rhinosinusitis / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery ; (12): 840-844, 2008.
Article Dans Chinois | WPRIM | ID: wpr-339256
ABSTRACT
<p><b>OBJECTIVE</b>To observe the presence of bacterial biofilms in mucosal specimens in patients operated for chronic rhinosinusitis.</p><p><b>METHODS</b>A total of 12 subjects undergoing endoscopic sinus surgery were included. The control group was 6 patients with obstructive sleep apnea-hypopnea syndrome. Six patients with chronic rhinosinusitis were enrolled in the study group. Mucosa of uncinate process, ethmoid bulla or maxillary sinus was obtained during endoscopic sinus surgery. All the samples were prepared using standard methods for scanning electron microscopy. Patients' information such as age, gender, symptoms, sinus CT, endoscopic examination, skin prick test were recorded in detail.</p><p><b>RESULTS</b>Standard-preparation scanning electron microscopy displayed denuded epithelium and disarrayed cilia in chronic rhinosinusitis patient's mucosa. In the study group, bacterial biofilms of different morphology were seen in five samples; One sample showed filamentous structure like fungi. Using strict scanning electron microscopy morphologic criteria, 83.3% samples in the study group were found to have micrographic evidence of biofilms. No bacterial biofilms were detected in the control group.</p><p><b>CONCLUSIONS</b>In the patients undergoing surgery for chronic rhinosinusitis, different degree of mucosal injury could be found. Bacteria biofilms of different life stages were demonstrated to be present. No bacterial biofilms were detected in the control group.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Sinusite / Microscopie électronique à balayage / Études cas-témoins / Maladie chronique / Biofilms / Microbiologie / Muqueuse nasale Type d'étude: Étude observationnelle Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Otorhinolaryngology Head and Neck Surgery Année: 2008 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Sinusite / Microscopie électronique à balayage / Études cas-témoins / Maladie chronique / Biofilms / Microbiologie / Muqueuse nasale Type d'étude: Étude observationnelle Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Otorhinolaryngology Head and Neck Surgery Année: 2008 Type: Article