Effect of large-dosage of 5alpha-reductase inhibitors on the spermatogenesis of male rats / 中华男科学杂志
National Journal of Andrology
;
(12): 652-654, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-339459
ABSTRACT
<p><b>OBJECTIVE</b>To identify the role of 5alpha-reductase in the spermatogenesis of male rats by studying the effect of two 5alpha-reductase inhibitors, Epristeride and Finasteride, on the spermatogenesis in male Sprague-Dawley (SD) rats.</p><p><b>METHODS</b>Changes in the weight of the testis, serum testosterone and dihydrotestosterone levels, epididymal sperm count, and reproductive function were observed and analyzed after the two 5alpha-reductase inhibitors were administered to male SD rats orally.</p><p><b>RESULTS</b>The experiment showed that in comparison with control animals, both the two 5alpha-reductase inhibitors 1. suppressed the development of the prostate and reduced the weight of the testis in the experimental groups (P < 0.05); 2. decreased the serum level of dihydrotestosterone and enhanced testosterone; 3. inhibited epididymal sperm count and productive function.</p><p><b>CONCLUSION</b>High dosages of the 5alpha-reductase inhibitor, Epristeride, can suppress the development of the prostate and reduce the weight of the testis, decrease dihydrotestosterone, and inhibit spermatogenesis and productive function in male rats.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Spermatogenèse
/
Rat Sprague-Dawley
/
Finastéride
/
Relation dose-effet des médicaments
/
Inhibiteurs de la 5-alpha réductase
/
Androstadiènes
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2005
Type:
Article
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