Effect of vasonatrin peptide on the expression of C-type natriuretic peptide receptor in hypoxic rat hearts / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 350-353, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-339717
ABSTRACT
<p><b>AIM</b>To investigate the effect of vasonatrin peptide (VNP) on the expression of C-type natriuretic peptide receptor (NPR-C) in hypoxic rat hearts.</p><p><b>METHODS</b>Rats were divided randomly into three groups control group, hypoxia group(3-28 d) and VNP (25-75 microg/kg per day) + hypoxia group. The plasma concentration of atrial natriuretic peptide (ANP) in rats was measured by the means of radioimmunoassay. Furthermore, quantitative PCR was used to examine the NPR-C mRNA level in rat hearts.</p><p><b>RESULTS</b>The plasma concentration ANP in rats was significantly higher than that of control group, and VNP (75 microg/kg per day) made it more higher. Hypoxia for 3 day of had no significant effect on the NPR-C mRNA level in rat hearts, while hypoxia for 7-28 d significantly increased the level of NPR-C mRNA in a time dependent manner. VNP (50-75 microg/kg per day) significantly reduced the NPR-C mRNA level in rat hearts in a dose dependent manner.</p><p><b>CONCLUSION</b>VNP increases the plasma concentration of ANP in hypoxic rats. Hypoxia can increase expression of NPR-C in rat hearts significantly, which can be inhibited by VNP.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Sang
/
Facteur atrial natriurétique
/
Récepteur facteur natriurétique auriculaire
/
Rat Sprague-Dawley
/
Peptide natriurétique de type C
/
Peptides natriurétiques
/
Hypoxie
/
Métabolisme
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Applied Physiology
Année:
2002
Type:
Article
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