Lymphocyte GRK2 expression of the very elderly with chronic heart failure / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 207-209, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-340193
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation of lymphocyte G protein-coupled receptor kinases 2 (GRK2) expression of the very elderly with chronic heart failure (HF) and heart ejection fraction (EF).</p><p><b>METHODS</b>16 elderly patients with chronic heart failure were divided into 2 groups as following EF < 45% (n=7), EF > or = 45% (n=9); and health elderly as control (n=8). Lymphocytes were obtained from blood, reverse transcription polymerase chain reaction were used to measure GRK2 mRNA levels.</p><p><b>RESULTS</b>Lymphocyte GRK2 mRNA levels of EF < 45% group were higher than that of EF > 45% group, which were greater than that of control.</p><p><b>CONCLUSION</b>Elevation of lymphocyte GRK2 levels in HF is associated with heart EF, lymphocytes may provide a surrogate for monitoring cardiac GRK2 in human HF.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Débit systolique
/
Sang
/
ARN messager
/
Lymphocytes
/
Maladie chronique
/
Kinase-2 associée au récepteur couplé à une protéine G
/
Génétique
/
Défaillance cardiaque
/
Métabolisme
Limites du sujet:
Adulte très âgé
/
Aged80
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Applied Physiology
Année:
2010
Type:
Article
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