Significance of chromosome 7 abnormalities in myeloid malignancies / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1739-1743, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-340426
ABSTRACT
Chromosome 7 abnormalities are the most common cytogenetic alterations found in myeloid malignancies. Myeloid malignancies exhibiting monosomy 7/del (7q) have been confirmed to associate with high susceptibility to infections, poor response to chemotherapy, and short survival time, so speculating that chromosome 7 has important tumor suppressor genes. Commonly deleted segments (such as 7q22) of chromosome 7 have been identified by FISH and other technologies. Genes (EZH2, MLL5, DOCK4, SAMD9L/SAMD9) located in commonly deleted segments of 7q have been cloned and characterized along with the advance of molecular biology.This review summaries the current advancement about myeloid malignancies associated with monosomy7/del(7q).
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Chromosomes humains de la paire 7
/
Leucémie myéloïde
/
Délétion de segment de chromosome
/
Génétique
/
Syndromes myéloprolifératifs
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2014
Type:
Article
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