Association between tumor necrosis factor-α G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1247-1253, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-340531
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between tumor necrosis factor-α (TNF-α) G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth (SPTB).</p><p><b>METHODS</b>The case group enrolled 753 SPTB infants and the control group included 681 term infants. TNF-α G-308A polymorphisms were genotyped using Sequenom MassARRAY®SNP.</p><p><b>RESULTS</b>The frequencies of the allele (G and A) in the case and control groups were not significantly different (P=0.35). The frequencies of the genotypes (GG, GA and AA) in the case and control groups were not significantly different (P=0.64). The logistic regression analysis found that TNF-α G-308A was not associated with genetic susceptibility to SPTB (OR=0.85; 95%CI 0.61-1.19; P=0.35).</p><p><b>CONCLUSIONS</b>There is no association between the polymorphisms of TNF-α G-308A and the genetic susceptibility to SPTB.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Facteur de nécrose tumorale alpha
/
Prédisposition génétique à une maladie
/
Polymorphisme de nucléotide simple
/
Naissance prématurée
/
Génétique
/
Génotype
Limites du sujet:
Femelle
/
Humains
/
Mâle
/
Nouveau-né
langue:
Chinois
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2016
Type:
Article
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