Association between interleukin-1β C+3953T and genetic susceptibility to spontaneous preterm birth: a case-control study / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1123-1129, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-340554
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between interleukin-1β (IL-1β) C+3953T and genetic susceptibility to spontaneous preterm birth (SPTB).</p><p><b>METHODS</b>In this case-control study, 753 SPTB neonates were enrolled in the case group and 681 full-term neonates were enrolled in the control group. The latest Sequenom MassARRAY®SNP detection technique was used for the typing of single nucleotide polymorphisms (SNP) of IL-1β C+3953T.</p><p><b>RESULTS</b>Compared with those carrying CC genotype of IL-1β C+3953T, the neonates who carried at least one T allele (CT+TT genotype) had significantly increased risks of SPTB, SPTB complicated by premature rupture of membranes, and mild preterm birth.</p><p><b>CONCLUSIONS</b>In the Chinese population, IL-1β C+3953T has significant genetic association with an increased risk of SPTB. The identification of this SNP helps to prevent SPTB and clarify the causes and pathogenesis of SPTB.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Études cas-témoins
/
Prédisposition génétique à une maladie
/
Polymorphisme de nucléotide simple
/
Naissance prématurée
/
Interleukine-1 bêta
/
Génétique
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
/
Mâle
/
Nouveau-né
langue:
Chinois
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2016
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS