Evaluation of the liver reserve using lidocaine test on experimental liver injuries in rats / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 445-448, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-341338
ABSTRACT
<p><b>OBJECTIVES</b>To study the effectiveness of the lidocaine test in evaluating the liver reserve of rats with experimental liver injury in different phases.</p><p><b>METHODS</b>40 healthy male Wistar rats were divided randomly into experimental and control groups. Rats of the experimental group received subcutaneous CCl4 in oil injection, and rats of the control group received saline injections. Monoethylglycinexylidide (MEGX) test, common hepatic function tests and histological examination of the livers were performed on all the rats.</p><p><b>RESULTS</b>With the development of the severity in liver injury, the concentrations of the serum MEGX in lidocaine test decreased gradually, which were consistent with liver histological changes. However, the results from the common liver function tests were all abnormal in the experimental group and were not consistent with the liver histological changes.</p><p><b>CONCLUSION</b>The results obtained from the MEGX test are more agreeable to liver histological changes than those from common liver function tests. The results from the MEGX test can represent liver histological changes concisely.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tétrachloro-méthane
/
Intoxication au tétrachlorure de carbone
/
Répartition aléatoire
/
Rat Wistar
/
Lidocaïne
/
Foie
/
Cirrhose expérimentale
/
Tests de la fonction hépatique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2006
Type:
Article
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