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Application of enriched bone marrow compound with fibrin glue in repairing old radial bone defect in rabbits / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 387-392, 2011.
Article Dans Chinois | WPRIM | ID: wpr-341397
ABSTRACT
<p><b>OBJECTIVE</b>To explore the feasibility of using enriched bone marrow (BM) compound with fibrin glue (FG) in repairing old radial bone defect.</p><p><b>METHODS</b>Totally 36 New Zealand rabbits were equally randomized into three groups simple FG group, BM+FG group, and enriched BM+FG group. A 1.5-cm segmental bone defect was made at the left radial in each animal. After one month, the defect was implanted with the engineered bone. Before implantation, a compound of enriched BM with FG underwent electron microscopy, long-term culture, and bacteriological culture. Four, 8, and 12 weeks after operations, the osteogenetic effect was evaluated using X-ray observation, HE staining, or Van Gieson staining, and a semi-quantitative analysis was performed.</p><p><b>RESULTS</b>Electron microscopy showed enriched BM were compatible well with FG. No bacterial contamination or oncogenicity was observed after long-term culture. X-ray showed the repair effectiveness was significantly higher in BM+FG group and enriched BM+FG group than in simple FG group. Eight and 12 weeks after surgery, the Yang scores were significantly higher in enriched BM+FG group than in BM+FG group [(9.348±0.364évs.(7.984±0.229éìF=40.167ìP=0.001; (12.664±0.388)vs. (10.584±0.836é, F=20.3647ìP=0.004]. In addition, the Yang's scores at bone defects in BM+FG group and enriched BM+FG group were higher at the 12(th) week than in the 8(th) week. (F=36.004ìP=0.001; F=155.141ìP=0.000; respectively)The bone defects were repaired at varied degrees were histologically observed in BM+FG group and enriched BM+FG group during the observations.</p><p><b>CONCLUSION</b>Implantation of BM+FG or enriched BM+FG are effective in repairing old radial bone defects, while simple FG shows not such effect.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Radius / Chirurgie générale / Plaies et blessures / Moelle osseuse / Colle de fibrine / Substituts osseux / Ingénierie tissulaire / Modèles animaux de maladie humaine Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Chinois Texte intégral: Acta Academiae Medicinae Sinicae Année: 2011 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Radius / Chirurgie générale / Plaies et blessures / Moelle osseuse / Colle de fibrine / Substituts osseux / Ingénierie tissulaire / Modèles animaux de maladie humaine Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Chinois Texte intégral: Acta Academiae Medicinae Sinicae Année: 2011 Type: Article