Study on the risk factors and its interaction on Parkinson disease / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 527-530, 2004.
Article
Dans Zh
| WPRIM
| ID: wpr-342319
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the risk factors of Parkinson disease (PD), interaction between family history of PD and other risk factors, as well as the relative strength of genetic factors over the vulnerability of PD.</p><p><b>METHODS</b>One 11 matched case-control study including 157 pairs of cases and controls was conducted in Qilu Hospital of Shandong University.</p><p><b>RESULTS</b>Conditional logistic regression analysis showed that family history of PD, mental labor, insecticide, alcohol drinking and history of depression all had positive relationship, while smoking had a negative relationship with PD. The AP (AB)s of family history of PD and insecticide, alcohol drinking, history of depression were 55.2%, 34.0%, 41.4% and the RERIs were 8.96, 3.31, 7.85 respectively. The heritability of PD patients' first degree relatives was 36.86% +/- 5.76%, and second degree relatives was 20.66% +/- 6.81%.</p><p><b>CONCLUSION</b>Family history of PD had an additive model synergism on PD, coexisting with other risk factors. Genetic factors had a smaller action on PD than environmental factors.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Maladie de Parkinson
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Pedigree
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Pesticides
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Consommation d'alcool
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Fumer
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Études cas-témoins
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Intervalles de confiance
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Modèles logistiques
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Modèles des risques proportionnels
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Santé de la famille
Type d'étude:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limites du sujet:
Adult
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Epidemiology
Année:
2004
Type:
Article