A study on risk factors among 125 type 2 diabetes mellitus with familial tendency / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 162-164, 2004.
Article
de Zh
| WPRIM
| ID: wpr-342362
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the risk factors regarding heredity and environment in familial incident type 2 diabetes mellitus (DM).</p><p><b>METHODS</b>To compare the difference of environmental risk factors between type 2 DM, impaired glucose tolerance (IGT) and normal persons through study on familial information and environmental risk factors in 125 familial incident type 2 DM in-patients and out-patients from 1999 to 2001. Falconer was used to estimate heritability. Penrose was used to study the heredity damagers by polygene analysis.</p><p><b>RESULTS</b>There was a significant constituent ratio diversity (P < 0.01) in triglyceride, body mass index, waist to hip ratio, hypertension history and physical activities history among 3 groups, while no significant diversity in blood lipids and history of coronary heart disease. 83.42% +/- 5.84% heritability of type 2 DM in 125 familial predigree indicated that dominant major gene might exist in these familiar pedigrees. Analysis of polygene in these groups showed type 2 DM might conform to the model of polygene heredity.</p><p><b>CONCLUSION</b>This study suggested that type 2 DM had significant heritability and genetic heterogeneity, which generally appeared to be a disease of multi-factorial inheritance. Environmental risk factors, genetic factors and their interactions were due to type 2 DM.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Triglycéride
/
Sang
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Pression sanguine
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Indice de masse corporelle
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Cholestérol
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Santé de la famille
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Facteurs de risque
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Diabète de type 2
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Génétique
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Hyperglycémie provoquée
Type d'étude:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Adult
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Female
/
Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Epidemiology
Année:
2004
Type:
Article