RNA interference in functional genomics and medical research / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 848-851, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-342597
ABSTRACT
RNA interference (RNAi) is a post-transcriptional gene silencing process by targeting mRNA for degradation in a sequence-specific manner. This powerful platform has enormous potential in functional genomics and medical research. As a tool to knock out expression of specific genes in a variety of organisms, RNAi was used to investigate gene function in a high throughput fashion. Highly conserved in evolution RNAi appears to have evolved as a cellular defense mechanism in plants and animals to suppress viral infection, transposon jumping and endogenous aberrant genes. Exploiting the natural mechanism, the researchers can shut down disease-causing genes and develop novel therapeutics against infection, tumor and other disease.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Régulation de l'expression des gènes
/
Extinction de l'expression des gènes
/
Génomique
/
Complexe réprimant l'expression de l'ARN
/
Petit ARN interférent
/
Interférence par ARN
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2004
Type:
Article
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