Effect of compound glycyrrhizin on peripheral T-lymphocyte subset in AIDS patients / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To probe the effect and mechanism of Compound Glycyrrhizin in treating AIDS.</p><p><b>METHODS</b>Forty AIDS patients were randomly divided into a treatment group and a control group, both treated with HAART. In addition, the former was given Compound Glycyrrhizin for 6 months, and the CD4+ T count and the expressions of CD8+ and HLA-DR on the surface of peripheral blood lymphocytes (PBL) were studied before and after the treatment.</p><p><b>RESULTS</b>After 6 months of treatment, the expressions of CD8+ and CD38+ of PBL in the treatment group [(6.6 +/- 2.1)%] were found lower than in the control [(11.4 +/- 3.8)%] (t = 5.043, P < 0.01) and CD4+ T count [(243.6 +/- 91.2) x 10(6)/L vs (170.8 +/- 55.7) x 10(6)/L] rose more significantly (t = 3.045, P < 0.01).</p><p><b>CONCLUSION</b>Compound Glycyrrhizin can lower the expression of active T-lymphocyte subset, inhibit HIV and help immune reconstitution.</p>