Altered expression of the HSD17B4 gene in esophageal squamous cell carcinoma and loss of heterozygosity analysis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 270-273, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-343724
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the alteration of the gene HSD17B4 in esophageal squamous cell carcinoma and its potential significance.</p><p><b>METHODS</b>The mRNA expression and loss of heterozygosity (LOH) of HSD17B4 in 40 primary esophageal tumors were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and microsatellite analysis with the intragenic marker D5S1384 of the gene.</p><p><b>RESULTS</b>The frequencies of allelic loss of D5S1384 and the rate of down-regulation of gene HSD17B4 were 46.2% and 62.5%, respectively.</p><p><b>CONCLUSION</b>HSD17B4 may be a candidate tumor suppressor gene associated with esophageal squamous cell carcinoma.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
ARN messager
/
Tumeurs de l'oesophage
/
Carcinome épidermoïde
/
Régulation négative
/
Expression des gènes
/
Régulation de l'expression des gènes tumoraux
/
Gènes suppresseurs de tumeur
/
Répétitions microsatellites
/
Perte d'hétérozygotie
/
RT-PCR
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2005
Type:
Article
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