Effect of combined continued hormone replacement therapy on knee osteoarthritis symptom of postmenopausal women / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 571-575, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-343807
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of combined continued estrogen and progestin replacement therapy on knee osteoarthritis (OA) symptoms of postmenopausal women.</p><p><b>METHODS</b>Sixty-four postmenopausal women with radiological knee OA and symptoms aged 45-75 were divided into treatment group and control group. They were given estradiol velerate (E2V) 1.0 mg/d and medroxyprogestetone acetate (MPA) 2 mg/d (treatment group) or placebo (control group) for 6 months. Calcium 400 mg/d were given to all cases. Then 0-100 mm visual analon scale (VAS) was used to evaluate the severity of knee pain at baseline and after 1, 3, 6 month of treatment.</p><p><b>RESULTS</b>Significant differences on pain at night and tenderness around knee were seen in the treatment group compared with the control group after 1 months of treatment (P = 0.036 and 0.035, respectively). The improvement of pain at night, during walk and morning stiffness between the two groups showed significant difference after 6 months (P = 0.026, 0.027, and 0.011, respectively).</p><p><b>CONCLUSION</b>Combined estrogen and progestin replacement therapy can relieve the knee OA symptoms of postmenopausal women.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oestrogénothérapie substitutive
/
Méthode en double aveugle
/
Études prospectives
/
Acétate de médroxyprogestérone
/
Post-ménopause
/
Gonarthrose
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Oestradiol
Type d'étude:
Essai clinique contrôlé
/
Etude diagnostique
/
Étude observationnelle
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2004
Type:
Article
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