CD34+ antigen expression relating to prognosis in acute myeloid leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 812-814, 2005.
Article
de Zh
| WPRIM
| ID: wpr-343881
Bibliothèque responsable:
WPRO
ABSTRACT
To explore CD34(+) antigen expression in new diagnosed acute myeloid leukemia (AML) and analyze the prognosis for CD34(+) AML patients, the expression of antigen CD34 in 238 AML patients was detected by indirect immunofluorescence assay. The results showed that CD34 in 92 out of the 238 patients (38.7%) were positive, there was relationship between the CD34(+) expression and FAB subtypes (M(0), M(1)), and no CD34(+) expression was observed in M(3) subtypes. The complete remission rate of CD34(+) AML patients was 32%, which was lower than that of CD34(-) AML (61%). The lymphoid-associated antigen (CD7) was significantly increased in CD34(+) AML patients, compared with CD34(-) patients (P < 0.05). It is concluded that CD34(+) AML patients show poor prognosis and lower CR rate. The detection of CD34 expression is of some value in predicting prognosis in AML.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
Pronostic
/
Leucémie aigüe myélomonocytaire
/
Leucémie aigüe myéloïde
/
Leucémie aigüe monoblastique
/
Technique d'immunofluorescence indirecte
/
Antigènes CD7
/
Antigènes CD34
/
Métabolisme
Type d'étude:
Prognostic_studies
Limites du sujet:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2005
Type:
Article