Advances in study of metabolic activation of carboxyl-acid containing drugs by UGTs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1193-1199, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-344094
ABSTRACT
The metabolic transformation of the drugs containing carboxylic acid groups can lead to the formation of acyl glucuronide metabolites through catalysis by glucuronosyltransferase, and produce pro-acyl glucuronide intermediate metabolites with electronic activity. Then, protein or DNA adducts appeared after a series of non-enzyme or enzyme reactions. These adducts would change the protein activity and potentially lead to idiosyncratic and genotoxicity. In this paper, we discussed the chemical activity, drug-induced mechanisms, distribution and toxicity resulting from this metabolic activation for these drugs, and stated the status and prospects of research in this field.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Transport biologique actif
/
Altération de l'ADN
/
Acides carboxyliques
/
Préparations pharmaceutiques
/
Biotransformation
/
Glucuronosyltransferase
/
Glucuronides
/
Hépatocytes
/
Effets secondaires indésirables des médicaments
/
Toxicité
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2009
Type:
Article
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