Progress in genetic research on essential tremor / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 767-771, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-344178
ABSTRACT
Essential tremor (ET) is one of the most common movement disorders. Its clinical manifestations not only include typical kinetic and/or postural tremors, but also other non-motor symptoms such as cognitive dysfunction, sleep disturbance, and dysosmia. The exact etiology and pathogenesis of ET is still unknown. Approximately 60% of ET patients have a family history, and genetic factor plays an important role in the onset of the disease. Researchers have so far identified 3 genetic loci (ETM 1-3) through family studies, and proposed additional causative genes such as FUS, HTRA2, TENM4, NOS3 and susceptibility genes such as LINGO, SLC1A2, and GABA. This review focuses on the progress made in genetic research on ET.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Prédisposition génétique à une maladie
/
Tremblement essentiel
/
Protéine FUS de liaison à l'ARN
/
Recherche génétique
/
High-temperature requirement A serine peptidase 2
/
Génétique
/
Protéines membranaires
/
Protéines de tissu nerveux
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2017
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS