C1772T polymorphism of hypoxia-inducible factor-1 alpha gene in Han ethnic population from Northern China / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 267-270, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-344338
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the distribution of single nucleotide polymorphism C1772T (SNP/C1772T) in hypoxia-inducible factor -1 alpha (HIF-1 alpha) gene in Han ethnic population from Northern China.</p><p><b>METHODS</b>Allele frequencies in a sample of 206 healthy Chinese Hans were determined by polymerase chain reaction followed by restriction fragment length polymorphism.</p><p><b>RESULT</b>The genotype frequencies of C1772T observed in Chinese Hans were 93 % and 7% for CC and CT respectively; and allele frequencies were 96% and 4 %for C and T respectively. There was significant difference in distribution of allele frequencies between Chinese Hans and Caucasian.</p><p><b>CONCLUSION</b>The single nucleotide polymorphism of C1772T in HIF-1 alpha gene has difference in different ethnic population.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Chine
/
Polymorphisme de nucléotide simple
/
Sous-unité alpha du facteur-1 induit par l'hypoxie
/
Ethnologie
/
Fréquence d'allèle
/
Génétique
/
Génotype
Limites du sujet:
Adolescent
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Journal of Zhejiang University. Medical sciences
Année:
2008
Type:
Article
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