Study on No.7 lymph nodes micrometastasis in patients with node- negative gastric carcinoma by routine examination / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 339-342, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-345176
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the micrometastatic characteristics in the gastric cancer patients with negative lymph node invasion by routine pathological examination and evaluate the relationship between micrometastasis and clinicopathological features.</p><p><b>METHODS</b>One hundred and thirty-eight lymph nodes from No. 7 group in 46 patients with node-negative gastric cancer by routine examination were examined by consecutive sections. Telomerase activity was determined by RT-PCR and ELISA. Clinicopathological data were analyzed by statistical method.</p><p><b>RESULTS</b>Micrometastasis was found in 32 lymph nodes (23.2%) from 13 cases (28.3%) by consecutive sections. Telomerase activity was positive in 49 lymph nodes (35.5%) from 20 cases (43.5%). The sensitivity, specificity, positive and negative predictive value and diagnostic accuracy of TRAP-ELISA was 100%, 84%, 65%, 100% and 88% respectively. The micrometastasis in lymph node was correlated with age, sex, primary tumor location, histological classification and metastatic lymph node type (P> 0.05), but correlated with the gross type of the primary tumor, size and serosa invasion (P< 0.05).</p><p><b>CONCLUSIONS</b>It is necessary to discern the micrometastasis in gastric cancer with negative lymph node by routine examination in order to objectively evaluate the clinicopathological classification and prognosis. TRAP-ELISA can be a complementary method to traditional histological examination.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tumeurs de l'estomac
/
Test ELISA
/
Valeur prédictive des tests
/
Sensibilité et spécificité
/
Telomerase
/
RT-PCR
/
Noeuds lymphatiques
/
Métastase lymphatique
/
Métabolisme
Type d'étude:
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Gastrointestinal Surgery
Année:
2005
Type:
Article
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