Advances of research on the mechanism of Down syndrome birth at advanced maternal age / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 863-866, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-345345
ABSTRACT
Down syndrome is caused by partial or complete triplication of genes located on chromosome 21. Its incidence increases dramatically with the age of women. Hypotheses proposed for this have included abnormal homologous recombination, defective spindle assembly, biological aging, reduction of cohesion complexes, endocrine disorders, oocyte selection model, and single nucleotide polymorphisms of genes that maintain chromosome stability, etc. A literature review is provided here.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ovocytes
/
Chromosomes humains de la paire 21
/
Vieillissement
/
Âge maternel
/
Syndrome de Down
/
Polymorphisme de nucléotide simple
/
Génétique
/
Métabolisme
Limites du sujet:
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2016
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS