The evaluation of cytocompatibility of mesenchymal stem cells on random biopolyster scaffolds / 生物医学工程学杂志

ABSTRACT

Mesenchymal stem cells (MSCs) were isolated from the bone marrow of rabbits and inoculated respectively on 3D scaffolds of poly (3-Hydroxybutyrate-co-3-Hydroxyvalerate) (PHBV), poly (butylenes succinate) (PBS) and the blends for evaluation of their cytocompatibilities in vitro. It was found that the blends of less microporous possessed the best performance on attachment and proliferation of MSCs in the six configurations. The toluiding blue staining showed the best morphology of mensenchymal stem cells (MSCs) on the blends of less microporous blends. The scanning electronic microscopy (SEM) results showed that the blends of less microporous blends had the appropriate roughness for MSCs to attach and proliferate, which can be used as a suitable biomaterial to create small caliber vascular grafts.