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Association between rs1079595 polymorphisms in the DRD2 gene and the distractibility based the temperament in school-age children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 270-274, 2015.
Article Dans Chinois | WPRIM | ID: wpr-346167
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between rs1079595 polymorphisms in the DRD2 gene and the distractibility in school-age children.</p><p><b>METHODS</b>The genotyping at rs1079595 was performed and the distractibility was measured based on the temperament questionnaire in 120 8-12 years old school-age children in order to analyze the effects of the rs1079595 polymorphism and its interaction with the gender, age and delivery mode on the distractibility.</p><p><b>RESULTS</b>There was an association between the distractibility and rs1079595 polymorphisms. The distractibility score in children with GG/GT genotypes was significantly higher than in children with the TT genotype (4.3 ± 0.6 vs 4.0 ± 0.7; P<0.05). The interaction between rs1079595 polymorphisms and the delivery mode produced an effect on the distractibility. The normal delivery children with T alleles were associated with a low distractibility (OR=0.037, P<0.01).</p><p><b>CONCLUSIONS</b>The distractibility based the temperament might be influenced by the rs1079595 polymorphism and its interaction with the delivery mode in school-age children.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Polymorphisme génétique / Tempérament / Modèles logistiques / Récepteur D2 de la dopamine / Accouchement (procédure) / Génétique / Génotype Type d'étude: Étude pronostique / Facteurs de risque Limites du sujet: Enfant / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Polymorphisme génétique / Tempérament / Modèles logistiques / Récepteur D2 de la dopamine / Accouchement (procédure) / Génétique / Génotype Type d'étude: Étude pronostique / Facteurs de risque Limites du sujet: Enfant / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2015 Type: Article