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Prognostic impact of loss of sex chromosomes in children with acute myeloid leukemia subtype M2 / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 168-171, 2015.
Article Dans Chinois | WPRIM | ID: wpr-346190
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between loss of sex chromosomes and prognosis in children with acute myeloid leukemia (AML) M2 subtype.</p><p><b>METHODS</b>According to cytogenetic characteristics, 106 children with AML were divided into three groups patients with normal karyotype (Group A, n=26), patients with abnormal karyotype who had no loss of sex chromosomes (Group B, n=52), and patients with abnormal karyotype who had loss of sex chromosomes (Group C, n=28). Prognosis was compared between the three groups.</p><p><b>RESULTS</b>The 5-year event-free survival (EFS) rates of Groups A, B, and C were (38.9±11.2)%, (59.3±7.3)%, and (66.5±10.5)%, respectively; the EFS of Group C was significantly higher than that of Group A (P=0.035). The 5-year overall survival (OS) rates of Groups A, B, and C were (54.3±13.5)%, (68.1±7.7)%, and (77.9±9.8)%, respectively (P>0.05). The 5-year EFS of 58 patients with t(8;21) was (63.3±7.3)%, significantly higher than that of patients with normal karyotype (P=0.015). All the 28 cases in Group C had t(8;21), and their 5-year EFS was not significantly different from that of patients with t(8;21) in Group B (P>0.05).</p><p><b>CONCLUSIONS</b>Loss of sex chromosomes is a favorable karyotype in children with AML M2 subtype and the patients in this group mostly have t(8;21). Why loss of sex chromosomes indicates a favorable prognosis is probably because it is accompanied by t(8;21) in the patients.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Aberrations des chromosomes sexuels / Translocation génétique / Chromosomes humains de la paire 8 / Chromosomes humains de la paire 21 / Leucémie aigüe myéloïde / Mortalité / Caryotype / Génétique Type d'étude: Étude pronostique Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Aberrations des chromosomes sexuels / Translocation génétique / Chromosomes humains de la paire 8 / Chromosomes humains de la paire 21 / Leucémie aigüe myéloïde / Mortalité / Caryotype / Génétique Type d'étude: Étude pronostique Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2015 Type: Article