Impact of splenectomy on the hepatic hemodynamics in patients received liver transplantation / 中华外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the changes of hepatic hemodynamics in patients with splenectomy plus living donor liver transplantation (LDLT).</p><p><b>METHODS</b>The data of 66 patients received LDLT from August 2006 to March 2009 were analyzed retrospectively22 cases received splenectomy with LDLT (splenectomy group) and aged (45 ± 11) years. Forty-four comparable cases received LDLT only in the mean time were selected as control group and aged (44 ± 10) years. Comparative analysis was performed between the two groups with respect to the changes of hepatic hemodynamics after transplantation.</p><p><b>RESULTS</b>Blood velocity in portal vein in control group and splenectomy group at 1 day before and after the transplantation were (12 ± 2) cm/s vs. (11 ± 3) cm/s, (35 ± 18) cm/s vs. (32 ± 17) cm/s, respectively. Postoperative blood velocity in portal vein in both groups increased significantly than the preoperative level (P < 0.05). Blood flow velocity in right hepatic vein in both groups at 1 week after the treatment were (44 ± 18) cm/s and (31 ± 15) cm/s (P < 0.05), respectively. Blood flow velocity in hepatic artery in both groups 2 weeks after the operation were (18 ± 8) cm/s vs. (26 ± 7) cm/s (P < 0.05) and resistance coefficient of hepatic artery were 0.66 ± 0.13 vs. 0.57 ± 0.12 (P < 0.05), respectively.</p><p><b>CONCLUSION</b>Hepatic hemodynamics in patients received LDLT plus splenectomy is superior to that in patients received LDLT only.</p>