Protective effect of yixinshu capsule on myocardial ischemia reperfusion injury in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2005-2008, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-346454
ABSTRACT
<p><b>OBJECTIVE</b>To observe the protective effect of Yixinshu capsule on myocardial ischemia reperfusion injury (MIRI) in SD rats.</p><p><b>METHOD</b>Sixty healthy SD rats were randomized into six groups sham group, MIRI model group, Xinsuning capsule group, low, middle or high dose Yixinshu capsule. Acute MIRI rat models were created by reperfusion for 120 min after anterior interventricular branch of the left coronary artery for 30 min. The serum creatine kinase (CK), lactic dehydrogenase (LDH), aspartate aminotransferase (AST) and malondialdehyde(MDA), blood viscosity, and infarction area of myocardium were determined.</p><p><b>RESULT</b>Yixinshu capsule could reduce serum CK, LDH, AST and LDH activity, improve the blood viscosity, and reduced the myocardial infarct size.</p><p><b>CONCLUSION</b>Yixinshu capsule can protect against MIRI in rats.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Viscosité sanguine
/
Capsules
/
Médicaments issus de plantes chinoises
/
Peroxydation lipidique
/
Lésion de reperfusion myocardique
/
Rat Sprague-Dawley
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Métabolisme
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2013
Type:
Article
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