Pharmacokinetics behavior of raltitrexed in rats after single injected with astragali radix / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1823-1826, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-346491
ABSTRACT
To study pharmacokinetics behavior of Raltitrexed (RTX) after single injected with Radix Astragali (RA); twelve rats were divided into two groups RTX (administrated iv. of raltitrexed); RTX with RA (administrated iv. of raltitrexed after single iv. dose of 3. 15 g x kg(-1)), rat plasma was collected and processed before HPLC assays; The established HPLC method was rapid, specific and precise. Between RTX and RTX with RA groups, half-life (t1/2), AUC(0-t) and CL showed no statistically significant differences; RA co-administration did not affect the pharmacokinetics of raltitrexed.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Quinazolines
/
Thiophènes
/
Médicaments issus de plantes chinoises
/
Pharmacocinétique
/
Chimie
/
Chromatographie en phase liquide à haute performance
/
Rat Sprague-Dawley
/
Astragalus
/
Interactions médicamenteuses
/
Antinéoplasiques
Limites du sujet:
Animaux
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2013
Type:
Article
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